Published June 1, 1984
by Springer .
Written in English
Nato a S I Series Series a, Life Sciences
|The Physical Object|
|Number of Pages||267|
"Proceedings of a NATO Advanced Study Institute on Principles and Methods in Receptor Binding, held September , , at Urbino, Italy"--Title page verso. Description: viii, pages: . Receptor autoradiography is an invaluable technique that is widely used to localize and characterize peptide and neurotransmitter binding sites. Its extensive use reflects the utility of the technique and the important advantages it offers over conventional biochemical procedures. Receptor Binding Techniques shows clearly how these methods can be adapted to many different applications and fully utilized in drug discovery programs. Publisher: Humana Press Inc. ISBN: Number of pages: Weight: g Dimensions: x x 23 mmAuthor: Mary Keen. A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors.
Principles and Methods in Receptor Binding F. Cattabeni Institute of Pharmacology and Pharacognosy University of Urbino Urbino, Italy S. Nicosia Institute of Pharmacology and Pharmacognosy University of Milan Milan, Italy UNIVERSITATS-BIBLIOTHEK Plenum Press New York and London Published in cooperation with NATO Scientific Affairs Division. Abstract. The aim of this chapter is to give a general overview of techniques employed in the process of ligand-receptor binding. The theoretical aspects of the ligand-receptor interactions and mathematical aspects of binding are not detailed here. “Overall, the book provides a balanced view from different leaders in the field and can thus be recommended to a larger audience consisting of, but not limited to, medicinal and computational chemists, structural biologists, as well as pharmacologists and scientists, who have an interest in drug discovery and the fascinating interplay between molecular recognition and structure.”. Buy Receptor Binding Techniques (Methods in Molecular Biology) by various,., Davenport, Anthony P. (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible various.
A drug receptor is a specialized target macromolecule that binds a drug and mediates its pharmacological action. These receptors may be enzymes, nucleic acids, or specialized membrane-bound proteins. The formation of the drug-receptor complex leads to a biological response. Thermodynamics and Kinetics of Drug Binding (Methods and Principles in Medicinal Chemistry Book 65) 1st Edition, Kindle Edition Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive Manufacturer: Wiley-VCH. Finally, modification of intramolecular flexibility was shown to play a role in optimizing the binding between receptors and ligands. In summary, our studies bring new insights to the general principles of ligand-receptor interactions. Future applications of our method will pave the way for new strategies to generate next-generation biologics. The relationship between the drug-receptor binding event and the ultimate biologic effect is complex. Quite often in experimental settings, the K D (concentration causing 50% receptor occupancy) does not correspond to a 50% maximal response from the test tissue or organism. In fact, in many cases half-maximal tissue responses are obtained at drug concentrations below the K D, suggesting that.